Gaddiel Rodriguez

Technical Advisor, Boston



Gaddiel Rodriguez is a technical advisor in the Intellectual Property Practice Group. He has extensive experience with methodologies and technologies involving proteins and nucleic acids.  

His practice focuses on a variety of intellectual property issues, including worldwide patent portfolio development, patent prosecution and IP due diligence in a broad range of life sciences subjects including matters involving gene therapy, genetic screens, enzyme replacement therapies, antibody development, fusion proteins, small molecules, pharmaceuticals, ocular products, protein therapeutics, immunology, drug formulations, and dosage regimens. 

Gaddiel received his Ph.D. in Molecular Biophysics at The Johns Hopkins University School of Medicine. His doctoral research focused on biochemical and biophysical characterization of protein-nucleic acid interactions, and intrinsically disordered proteins involved in DNA repair.

Biochemistry and Chemistry
Hunter College
Molecular Biophysics
The Johns Hopkins University School of Medicine


Gaddiel has performed due diligence investigations of the intellectual property portfolios directed to gene therapy, small molecule, ocular therapeutics, and biopharmaceutical companies.  He regularly assists with intellectual property matters involving freedom to operate analyses, inter partes review, strategic transactions, and due diligence.


Rodriguez G, et al. Macromolecular crowding induces compaction and DNA binding in the disordered N-terminal domain of hUNG2.  DNA Repair (Amst).  2020 Feb;86:102764

Weiser BP, Rodriguez G, Cole PA, Stivers JT.  N-terminal domain of human uracil DNA glycosylase (hUNG2) promotes targeting to uracil sites adjacent to ssDNA-dsDNA junctions.  Nucleic Acids Res. 2018 Aug 21;46(14):7169-7178

Esadze A, Rodriguez G, Weiser BP, Cole PA, Stivers JT.  Measurement of nanoscale DNA translocation by uracil DNA glycosylase in human cells.  Nucleic Acids Res. 2017 Dec 1;45(21):12413-12424

Rodriguez G, et al.  Disordered N-Terminal Domain of Human Uracil DNA Glycosylase (hUNG2) Enhances DNA Translocation.  ACS Chem Biol. 2017 Sep 15;12(9):2260-2263

Esadze A, Rodriguez G, Cravens SL, Stivers JT.  AP-Endonuclease 1 Accelerates Turnover of Human 8-Oxoguanine DNA Glycosylase by Preventing Retrograde Binding to the Abasic-Site Product.  Biochemistry. 2017 Apr 11;56(14):1974-1986