Biography
Gaddiel Rodriguez is an associate in the Intellectual Property practice group. His practice focuses on strategic patent counseling, worldwide patent portfolio development, and litigation. Gaddiel has extensive experience in a broad range of life sciences subject matter, including biologics, fusion proteins, antibody development, enzyme replacement therapies, protein therapeutics, gene therapy, genetic screens, small molecules, vaccines, pharmaceuticals, ocular products, immunology, drug formulations, dosage forms and regimens.
Gaddiel received his Ph.D. in Molecular Biophysics at The Johns Hopkins University School of Medicine. His doctoral research focused on biochemical and biophysical characterization of protein-nucleic acid interactions, and intrinsically disordered proteins involved in DNA repair.
Rodriguez G, et al. Macromolecular crowding induces compaction and DNA binding in the disordered N-terminal domain of hUNG2. DNA Repair (Amst). 2020 Feb;86:102764
Weiser BP, Rodriguez G, Cole PA, Stivers JT. N-terminal domain of human uracil DNA glycosylase (hUNG2) promotes targeting to uracil sites adjacent to ssDNA-dsDNA junctions. Nucleic Acids Res. 2018 Aug 21;46(14):7169-7178
Esadze A, Rodriguez G, Weiser BP, Cole PA, Stivers JT. Measurement of nanoscale DNA translocation by uracil DNA glycosylase in human cells. Nucleic Acids Res. 2017 Dec 1;45(21):12413-12424
Rodriguez G, et al. Disordered N-Terminal Domain of Human Uracil DNA Glycosylase (hUNG2) Enhances DNA Translocation. ACS Chem Biol. 2017 Sep 15;12(9):2260-2263
Esadze A, Rodriguez G, Cravens SL, Stivers JT. AP-Endonuclease 1 Accelerates Turnover of Human 8-Oxoguanine DNA Glycosylase by Preventing Retrograde Binding to the Abasic-Site Product. Biochemistry. 2017 Apr 11;56(14):1974-1986